Spruce Pine is located in Western North Carolina, about 40 miles north of Asheville. The town is located in Mitchell County.

 Major roads:

- NC route 226
- US highway 19-E

Driving time to various cities:

• Marion, NC  (25 mins)
  
• Boone, NC  (50 mins)
  
• Asheville, NC  (1 hour)
• Johnson City, TN  (1 hour)
• Hickory, NC  (1.5 hours)
  
• Greenville, SC  (2 hours)
  
• Charlotte, NC  (2.5 hours)
  
• Atlanta, GA  (4 hours)